Circadian clocks are present in all cells of the body, and have a pervasive influence on all aspects of human physiology. This is because they regulate homeostasis by anticipating rhythmic changes in behavior and nutritional state, and by compartmentalizing incompatible metabolic pathways within precise temporal windows. For example, it is known that shift workers are particularly susceptible to metabolic diseases such as diabetes. In their recent work, the team led by Uhlenhaut turned their attention to the hour metabolic rhythm of muscles.
Semb aims to develop safe approaches for up-scaled production of insulin-producing beta cells from human pluripotent stem cells hPSCs. He and his team have recently made major breakthroughs towards this goal. The scientists were able to establish a technology which allows the precursors of beta cells to be selectively isolated from a heterogeneous pool of differentiated hPSCs.
As a next step, Gute gratis singleborse munchen 100 free dating sites northern ireland and his team found new ways to specifically promote the proliferation of these beta cell precursors.
Semb's long-term objective is to cree a safe and scalable stem cell therapy for people with type 1 diabetes. An important milestone in the short term is the proper production of the cells following defined standards of Good Manufacturing Practice GMP. If their destruction exceeds a certain extent, the beta cells can no longer produce the glucose-lowering hormone insulin, and the metabolism gets out of control.
More information in German on this topic at: Since quality deviations can have a direct impact on the health of consumers, quality assurance plays a key role in pharmaceutical manufacturing. Helmholtz - Gemeinschaft Deutscher Forschungszentren. We Partnersuche dating Halle kostenlose bekanntschaftsanzeigen Osnabruck cookies to improve gratia experience on our Website.
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Henrik Semb to lead new Institute of Translational Stem Cell Research
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