The immune system protects the human body against pathogens thus keeping it healthy. To achieve this, however, immune cells must be able to recognise intruders and to classify them as dangerous or harmless. These tasks are shared among different cell types: If an immune cell recognises foreign matter, it can present it to another immune cell. Both cells form a characteristic ring-shaped structure at their contact point, the immunological synapse, through which they exchange information.
Pulmonary fibrosis is associated with the increased formation of connective tissue in the lungs, resulting in scarring fibrosis of functional lung tissue. This leads Best america dating site im single quotes for facebook a decrease in the inner surface of the extremely fine alveoli and the extensibility of the lungs, which, in turn, impedes the intake of oxygen and the release of carbon dioxide.
The result is impaired lung function. IPF is a particularly aggressive form of the disease that cannot be attributed to a specific cause.
The symptoms worsen rapidly. Existing drugs can slow progression of the disease but are unable to stop it permanently. Research is therefore continuing to focus on elucidating the mechanisms underlying the pathological tissue changes associated with IPF.
It is already known that the signaling molecule WNT5A is responsible for Best america dating site im single quotes for facebook the proliferation of connective tissue cells in the lungs.
Mareike Lehmann, one of the authors of the study. Until recently, it was unclear whether and how extracellular vesicles are implicated in IPF. In further preclinical studies, the researchers now want to examine the suitability of extracellular vesicles as a pharmacological biomarker, as well as a possible therapeutic target.
American journal of respiratory and critical care medicine To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The CPC's objective is to conduct research on chronic lung diseases in order to develop new diagnosis and therapy strategies.
The CPC maintains a focus on experimental pneumology with the investigation of cellular, molecular and immunological mechanisms involved in lung diseases. The CPC's objective is to conduct research on chronic lung diseases in order to develop new diagnostic tools and therapies.
The LRR Research Unit examines new mechanisms and repair processes in the lungs for a better understanding that will allow the development of new therapeutic approaches.
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